|
|
Summary
Table: Rates of death and sequelae according to treatment regimen |
|||||||||||||
|
|
|
regimen 1 |
regimen 2 |
regimen 3 |
|
|||||||||
|
Author Date |
level of evidencea |
regimenb |
n |
death (%) |
sequelae (%) |
regimenb |
n |
death (%) |
sequelae (%) |
regimenb |
n |
death (%) |
sequelae (%) |
Statistical analysis |
|
Visudhiphan 1975 |
4 |
18HSP |
13 |
4 (30.8) |
6 (46.2) |
4HR/14HP |
20 |
1 (5.0) |
7 (35.0) |
|
|
|
|
nonee |
|
Chandra 1976 |
2b |
?HSP |
38 |
13 (34.2) |
15 (39.5) |
?HRE |
42 |
4 (9.5) |
6 (14.3) |
|
|
|
|
death:
p<0.05f sequelae:
p<0.01f |
|
Girgis 1976 |
4 |
2HSP/22HP |
44 |
15 (34.1) |
1 (2.3) |
2HSE/22HE |
42 |
16 (38.1) |
1 (2.4) |
|
|
|
|
death:nsfg |
|
Girgis 1978 |
2b |
2HSE/22HE |
35 |
17 (48.6) |
6 (17.1) |
2HSR/22HR |
36 |
18 (50.0) |
6 (16.7) |
|
|
|
|
none |
|
Rahajoe 1979 |
2b |
3HSP/9HP/6H |
19 |
5 (26.3) |
11 (57.9) |
1HSR/5HR/12H |
22 |
6 (27.3) |
7 (31.8) |
|
|
|
|
death: nsf sequelae: nsf
0.10>p>0.05 |
|
Sunakorn 1980 |
4 |
2HSP/10HP |
17 |
8 (47.1) |
4 (23.5) |
6HR/6HP |
16 |
5 (31.3) |
3 (18.8) |
2HRSE/4HRE |
16 |
1 (6.3) |
9 (56.3) |
death:ns
(p=0.3)fg for 1v2 death:
p<0.05fg for 1v3 |
|
Ramachandran 1986 |
4 |
2HRS/4HS2E/6HE |
69 |
18 (26.1) |
28 (40.6) |
2HRZS/10HE |
24 |
8 (33.3) |
9 (37.5) |
2HR2ZS/10HE |
70 |
18 (25.7) |
27 (38.6) |
none |
|
Humphries 1990c |
4 |
P,H,S,R,E,Z,Eth |
199 |
13 (65.3) |
63 (31.7) |
|
|
|
|
|
|
|
|
no
associationsi |
|
Jacobs 1992 |
4 |
2(H/R)SE/10(H/R)E |
4 |
2 (50.0) |
2 (50.0) |
2HRS/7HR |
4 |
2 (50.0) |
2 (50.0) |
2HRZS/4HR |
45 |
7 (15.6) |
11 (24.4) |
death: nsfh sequelae:p=0.0048fh death&sequelae:p=0.0012fh |
|
Porkert 1997c |
4 |
?HRZ(E/S), ?HRZ, ?HRd |
34 |
17 (50.0) |
6 (17.6) |
|
|
|
|
|
|
|
|
no
associationsi |
|
a
according to the Oxford Centre for Evidence Based Medicine bwritten
in standard TB therapy code c
numbers for individual regimens not stated dno
treatment length stated eno
analysis performed by author but p=0.044 using 'Chi-square test (Table in
Worksheet)' function in MiniTab f Χ2
test g
sequelae not analysed h
statistics are for regimen 3 v regimens 1&2 combined i no
statistical associations between treatment regimen and outcome n=number of patients assigned to regimen;
P=para-aminosalicylic acid; H=isoniazid; S=streptomycin; E=ethambutol;
R=rifampicin; Z=pyrazinamide; Eth=ethionamide; ?=treatment duration not
known; ns=not significant; none=statistics not performed |
||||||||||||||