|
Author Design |
Country Setting |
Sample Size |
Inclusion Criteria |
Intervention |
Results |
LOE |
|
Lokesh et al 2004 RCT |
Hospital Intensive Care
Unit |
55 |
Asphyxiated neonates continuing to need positive pressure ventilation
at 5 min of life No congenital
malformations |
Bicarbonate Group (n=27) Given 4ml/kg(1.8
meq./kg sodium bicarbonate over 3-5 minutes Dextrose Group (n=28) Given 4ml/kg of
undiluted 5% dextrose over 3-5 minutes Outcomes
Death or abnormal neurological examination at discharge.
Encephalopathy, multi-organ dysfunction, intraventricular
haemorrhage (IVH) and arterial pH at 6 h |
Death
or Abnormal Neurological Examination at discharge
Bicarb group =52% Dextrose group
=54% (P =0.88) Incidence
of Encephalopathy
Bicarp group =74% Dextrose group
=63% Incidence
of Cerebral Oedema
Bicarp group =52% Dextrose group
=30% Need
for Inotropic Support
Bicarp group = 44% Dextrose group
=29% Mean
arterial pH at 6 hrs were similar between the two groups.
Survival
to Discharge
Bicarb group=18/27(66.7%) Dextrose
group=19/28(68%) (P=0.84) Neurologically Abnormal at Discharge
Bicarb group=28% of the survivors Dextrose group=32%
of the survivors (P=0.10). |
1b |
|
Murki et al 2004 RCT |
Neonatal
Intensive Care Unit |
55 |
Asphyxiated neonates continuing to need positive pressure ventilation
at 5 min of life No congenital
malformations |
Base Group (n=27) Given 4ml/kg(1.8
meq./kg sodium bicarbonate over 3-5 minutes Dextrose Group (n=28) Given 4ml/kg of
undiluted 5% dextrose over 3-5 minutes Outcomes
Acid-base status
at 1,6,12, and 24 hours of life, need for ventilation, duration of
respiratory distress, need for inotropes, duration
of inotropes, seizures, cerebral edema and
encephalopathy |
The mean pH,
base deficit and PaCO2 were similar at 24 hours of life Mean pH Base group =7.38
± 0.15 Control group
=7.38 ± 0.07 Base
Deficit
Base group =4.26
± 4.60 Control
group=5.02 ± 5.76 PaCO2 Base group
=34.67 ± 15 Control group
=32.67 ± 7.83 Acidosis
at 24 Hours
Base group =3[12%] Control group =7[28%] All
p-values>0.05 |
1b |