Table 1. Performance of basic clinical indicators in diagnosing TB in children

Study	Design	Setting	Sample size	Gold standard	Indicator	Performance
Marias et al, 2006 [7]	Prospective	Community based. Cape Town, South Africa.	428	Microbiology OR diagnostic radiology OR suggestive radiology AND response to therapy	Cough > 2 weeks, objective weight loss and reported fatigue	In low risk children (> 3years and HIV -ve) sensitivity 82%, specificity 90%, PPV 82%. In high risk, sensitivity 52%, specificity 93%, PPV 90%.
					Cough > 2 weeks, objective weight loss and TST >10mm	In children < 3 years (HIV –ve), sensitivity 67%, specificity 94%, PPV 90%.