Table 4. Performance of clinical indicators in diagnosing TB in children with HIV

Study	Design	Setting	Sample size	Gold standard	Indicator	Performance
Marias et al, 2006 [7]	Prospective	Community based. Cape Town, South Africa.	Subset of 428, 297 tested (37 HIV positive)	Microbiology OR diagnostic radiology OR suggestive radiology AND response to therapy	Persistent non-remitting coughing > 2 weeks, objective weight loss and reported fatigue	Sensitivity 56%, Specificity 62%, PPV 62%.
Van Rheenan, 2002 [38]	Prospective	Hospital, Copperbelt Zambia	147	Microbiology OR diagnostic radiology OR (Mantoux OR suggestive radiology) AND response to therapy	Keith Edwards score > 7	Sensitivity 88%, Specificity 25%.