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Table 3 Pathogens identified from lung in post mortem studies (%) |
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Pathogen |
Chintu C14,§ |
Nathoo KJ15,p |
Wolf BH16,b |
Jeena PM17,y |
Lucas SB18,§ |
Ansari NA19,§ |
Rennert WP20,§ |
Ikeogu MO21,g |
Ruffini DD12,p |
Total |
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|
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
HIV+ n (%) |
HIV- n (%) |
|
No of
patients |
130* |
61* |
24 |
0 |
122 |
90 |
36 |
36 |
36** |
29** |
35 |
12 |
93 |
0 |
122 |
62 |
18 |
0 |
616 |
290 |
|
Age (months) |
1-17 |
1-17 |
<6 |
|
0-60 |
0-60 |
1-18 |
1-18 |
1-14 |
1-14 |
1m-13yl |
1m-13yl |
1-70 |
|
1-55 |
1-42 |
2-24 |
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M. tuberculosis |
22 (16.9) |
13 (21.3) |
0 (0) |
0 (0) |
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|
1 (2.7)§ |
0 (0)§ |
0 (0) |
0 (0) |
4 (11.4) |
1 (8.3) |
4 (4.3) |
- |
6 (4.9) |
2 (3.2) |
1 (5.6) |
- |
38 (6.2) |
16 (5.5) |
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Gram +ve |
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S. aureus |
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|
3 (12.5) |
- |
2 (1.6) |
3 (3.3) |
1 (2.8) |
4 (11.1) |
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|
8 (6.6) |
4 (6.5) |
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|
14 (2.3) |
11 (3.8) |
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S.
pneumoniae |
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3 (2.5) |
1 (1.1) |
0 (0) |
1 (2.8) |
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|
10 (8.2) |
4 (6.5) |
1 (5.6) |
|
14 (2.3) |
6 (2.1) |
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Group A
strep |
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|
3 (2.5) |
2 (2.2) |
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|
3 (2.5) |
2 (3.2) |
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|
6 (1.0) |
4 (1.4) |
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Group B
strep |
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1 (0.8) |
0 (0) |
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|
1 (0.2) |
0 (0) |
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Other Gram
+ve |
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|
12 (9.8) |
6 (6.7) |
2 (5.6) |
0 (0) |
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|
5 (4.1) |
3 (4.8) |
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|
19 (3.1) |
9 (3.1) |
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Gram –ve |
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Klebsiella
spp |
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|
2 (8.3) |
- |
19(15.6) |
12(13.3) |
2 (5.6) |
1 (2.8) |
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|
28 (23.0) |
16 (25.8) |
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|
51 (8.3) |
29 (10.0) |
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Pseudomonas spp |
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|
7 (5.7) |
1 (1.1) |
6 (16.7) |
4 (11.1) |
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|
6 (4.9) |
1 (1.6) |
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|
19 (3.1) |
6 (2.1) |
|
E. coli |
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|
4 (16.6) |
- |
11 (9.0) |
4 (4.4) |
1 (2.8) |
0 (0) |
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|
16 (2.6) |
4 (1.4) |
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Coliforms |
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|
8 (6.6) |
7 (11.2) |
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|
8 (1.3) |
7 (2.4) |
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H.
influenzae |
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|
0 (0) |
3 (3.3) |
0 (0) |
1 (2.8) |
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|
2 (1.6) |
3 (4.8) |
1 (5.6) |
- |
3 (0.5) |
7 (2.4) |
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Salmonella spp |
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|
3 (2.5) |
0 (0) |
0 (0) |
1 (2.8) |
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|
1 (5.6) |
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4 (0.6) |
1 (0.3) |
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Salmonella typhi |
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1 (0.8) |
0 (0) |
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|
1 (0.2) |
0 (0) |
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H.
influenzae B |
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|
0 (0) |
1 (2.8) |
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|
0 (0) |
1 (0.3) |
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Other Gram
-ve |
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|
2 (1.6) |
2 (2.2) |
2 (5.6) |
2 (5.6) |
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|
2 (1.6) |
1 (1.6) |
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|
6 (1.0) |
5 (1.7) |
|
Virus |
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|
CMV |
39 (30.0) |
2 (3.3) |
2 (8.3) |
- |
|
|
16 (4 4.4)§ |
1 (2.8)§ |
16 (44.4) |
3 (10.3) |
8 (22.9) |
0 (0) |
18 (19.4) |
- |
9 (7.4) |
0 (0) |
8 (44.4) |
- |
115 (18.7) |
6 (2.1) |
|
RSV |
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|
2 (5.6) |
1 (2.8) |
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|
4 (11.4) |
0 (0) |
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|
1 (5.6) |
|
7 (1.1) |
1 (0.3) |
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Parainfluenza |
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|
3 (8.3) |
1 (2.8) |
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3 (0.5) |
1 (0.3) |
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Adenovirus |
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|
2 (5.6)§ |
5(13.8)§ |
0 (0) |
1 (3.4) |
1 (2.9) |
0 (0) |
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|
3 (0.5) |
6 (2.1) |
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Other
virus |
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|
7 (19.4) |
12 (33.3) |
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|
13 (14.0) |
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|
20 (3.2) |
12 (4.1) |
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Fungi |
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P. jiroveci |
47 (36.2) |
6 (9.8) |
6 (25.0) |
- |
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|
16 (44.4)§ |
0 (0)§ |
11 (30.6) |
0 (0) |
10 (28.6) |
0 (0) |
10 (10.7) |
- |
19 (15.6) |
0 (0) |
8 (44.4) |
|
127 (20.6) |
6 (2.1) |
|
C.
albicans |
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|
1 (0.8) |
0 (0) |
1 (2.8)§ |
0 (0)§ |
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|
2 (0.3) |
0 (0) |
* Subset of
cohort (age 1-17months) p Post
mortem biopsy/blood culture
** Subset of cohort (age 1-14months) g Post
mortem biopsy/percutaneous lung aspirate
§ Post mortem
biopsy y Ante
mortem blood culture
b Post mortem blood culture l Median age
10 month