Table
1: Included studies
|
Reference |
Sample
Size |
Gold
standard for diagnosis |
Sensitivity |
Specificity |
+ve Likelihood Ratio |
-ve Likelihood Ratio |
|
Sherman
[2] |
203
samples from 90 infants aged 0-7 months |
DNA PCR |
98.10 |
98.70 |
74.00 |
0.02 |
|
85 samples
from 6 week old infants |
|
95.70 |
100.00 |
α |
0.04 |
|
|
82
samples from 3 month old infants |
|
100.00 |
100.00 |
α |
0.00 |
|
|
5
samples from 4 month old infants |
|
100.00 |
100.00 |
α |
0.00 |
|
|
31
samples from 7 month old infants |
|
100.00 |
92.00 |
12.00 |
0.00 |
|
|
|
|
|
|
|
|
|
|
Fiscus [3] |
802
specimens from 582 infants aged 0-180 days |
DNA PCR |
91.70 |
98.50 |
61.13 |
0.09 |
|
114
samples from infants aged 0-7 days |
|
β |
99.90 |
β |
1.00 |
|
|
180
samples from infants aged 8-30 days |
|
90.00 |
98.01 |
69.23 |
0.10 |
|
|
367
samples from infants aged 31-90 days |
|
93.30 |
98.00 |
46.65 |
0.07 |
|
|
141
samples from infants aged 91-180 days |
|
94.10 |
97.70 |
40.91 |
0.06 |
|
|
|
|
|
|
|
|
|
|
Sutthent [4] |
242
samples taken from infants aged 1-6 months |
DNA PCR |
100.00 |
100.00 |
α |
0.00 |
|
121
samples taken from infants aged 1-2 months |
|
100.00 |
100.00 |
α |
0.00 |
|
|
121
samples taken from infants aged 4-6 months |
|
100.00 |
100.00 |
α |
0.00 |
|
|
|
|
|
|
|
|
|
|
Nadal [5] |
643
samples from 246 infants and children |
DNA PCR |
85.37 |
98.80 |
70.85 |
0.14 |
|
12
samples from infants aged 0-10 days |
|
50.00 |
98.65 |
37.00 |
0.51 |
|
|
10
samples from infants aged 11 days - 3 months |
|
100.00 |
98.28 |
58.00 |
0.00 |
|
|
19
samples from infants aged 3-6 months |
|
100.00 |
100.00 |
α |
α |
|
|
|
|
|
|
|
|
|
|
Zijenah [6] |
164
infants aged between 0-18 months |
DNA PCR |
96.70 |
96.10 |
24.79 |
0.03 |
|
85
infants aged 0-6 months |
|
98.10 |
96.90 |
31.65 |
0.02 |
|
|
79
infants aged between 7-18 months |
|
89.50 |
91.10 |
10.06 |
0.12 |
|
|
|
|
|
|
|
|
|
|
Lyamuya [7] |
231
samples from infants aged 0-30 months |
DNA PCR |
98.40 |
100.00 |
δ |
0.02 |
|
18
samples from infants aged 1-8 weeks |
|
100.00 |
Δ |
δ |
δ |
|
|
36
samples from infants aged 9-26 weeks |
|
97.20 |
Δ |
δ |
δ |
|
|
40
samples from infants aged 27-52 weeks |
|
100.00 |
Δ |
δ |
δ |
|
|
25
samples from infants aged 13-18 months |
|
96.00 |
Δ |
δ |
δ |
|
|
|
|
|
|
|
|
|
|
α |
There are no false +ve's or
false -ve's in this data |
|||||
|
β |
Author stated the data set was too small for accurate
analysis |
|||||
|
γ |
Author states sensitivities and specificities but does
not state likelihood ratios or the raw data |
|||||
|
δ |
Author only gives raw data for children who tested +ve for HIV |
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